Can you visualize the situation when you are able to afford absolutely everything including cakes, cookies, ice cream and other tasty things without any consequences? You will be able to eat anything and no weight gain will follow then. Is it possible? What do you think? The researchers were also interested in the same question and began to explore the issue.
The research was conducted that determined that such situation is just not possible. Researchers from the USC Davis School of Gerontology and Keck School of Medicine of USC discovered a method of struggle with obesity that often goes along with high sugar diet. The medications developed medications to target a key gene.
The work was conducted in a petri dish. The researchers examined the human cells and the cells of worm Caenorhabditis elegans to discover the genetic pathway that is actually present in nearly all mammals and even yeast. Then they were going to test it in mice.
The research was published in the journal Nature communications.
Basing the research on former work, the specialists discovered genetic mutants with hyperactive SKN-1 gene, which were on high-sugar diet and no weight was gained. However, C. elegans had the same nutrition and enlarged on it.
Bacteria consuming high-sugar diet is the same as a person on western diet. This nutrition is known to all in western countries, when food contains much fat and much sugar. People who consume fast food and soda regularly are on western diet.
Not only animals have the SKN-1 gene. It is present in the organisms of people and known as Nrf2. The scientists studied the Nrf2 protein well, which is a factor bound to a certain sequence of DNA in order to regulate properties of cells to detox and recover after exposure to chemically reactive oxygen that present danger for existence of cells.
Pharmaceutical companies did everything for development of small-molecule medications that work over Nrf2, trying to reach success in the production of more anti-oxidants that postpone aging.
In spite of the fact that desire to develop a pill that controls aging of the organism sounds attractive, it still brings some risk because higher activity of Nrf2 is connected with aggressive forms of cancer.